KChIPs and Kv4 Subunits as Integral Components of A-Type Potassium Channels in Mammalian Brain
نویسندگان
چکیده
Kenneth J. Rhodes,1 Karen I. Carroll,1 M. Amy Sung,1 Lisa C. Doliveira,1 Michael M. Monaghan,1 Sharon L. Burke,1 Brian W. Strassle,1 Lynn Buchwalder,2 Milena Menegola,4 Jie Cao,3 W. Frank An,3 and James S. Trimmer2,4 1Neuroscience, Wyeth Discovery Research, Princeton, New Jersey 08543, 2Department of Biochemistry and Cell Biology, State University of New York, Stony Brook, New York 11794, 3Millennium Pharmaceuticals, Cambridge, Massachusetts 02139, and 4Department of Pharmacology, School of Medicine, University of California, Davis, California 95616
منابع مشابه
Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain.
Kv4 family voltage-gated potassium channel alpha subunits and Kv channel-interacting protein (KChIP) and dipeptidyl aminopeptidase-like protein subunits comprise somatodendritic A-type channels in mammalian neurons. Recently, a mouse was generated with a targeted deletion of Kv4.2, a Kv4 alpha subunit expressed in many but not all mammalian brain neurons. Kv4.2-/- mice are grossly indistinguish...
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تاریخ انتشار 2004